Histone inhibition

US9226939B2 · kind B2 · utility

Assignee

• The Australian National University · AU

Inventors

• Ross Stephens · North Canberra, AU
• Christopher Richard Parish · Campbell, AU
• Craig Geoffrey Freeman · Weston Creek, AU
• Timothy John Senden · North Canberra, AU

Key dates

• Filing date: Nov 29, 2011
• Grant date: Jan 5, 2016
• Expiry date: Jan 8, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a method of inhibiting the cytotoxic activity of extracellular histones in a subject, comprising administering an effective amount of a polyanion to the subject. In particular the invention relates to a method for the treatment of patients who are suffering from sepsis and employs polyanions to rapidly form complexes with and thus neutralize or inhibit the cytotoxic activity of extracellular histone proteins, for example, those found in the blood circulation of sepsis patients.