Patent · US Active

Variants of plasminogen and plasmin

US9226953B2 · kind B2 · utility

1Cited by

39References

46Claims

0Family size

Assignee

ThromboGenics NV · BE

Inventor

Richard Zwaal · Gent, BE

Key dates

Filing date	Jul 9, 2010
Grant date	Jan 5, 2016
Priority date	—
Expiry date	Nov 19, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y304/21007
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to variants of plasminogen and plasmin comprising one or more point mutations in the catalytic domain which reduce or prevent autocatylic destruction of the protease activity of plasmin. Compositions, uses and methods of using said variants of plasminogen and plasmin are also disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.