Human CD3-specific antibody with immunosuppressive properties

US9226962B2 · kind B2 · utility

Assignee

• AFFIMED GMBH · DE

Inventors

• Fabrice Le Gall · Mainz, DE
• Sergey Kipriyanov · Heidelberg, DE
• Melvin Little · Neckargemünd, DE
• Uwe Reusch · Maikammer, DE

Key dates

• Filing date: Jan 11, 2013
• Grant date: Jan 5, 2016
• Expiry date: May 29, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described are mono- and multivalent scFv-antibodies comprising the binding sites specific for the human T cell marker CD3. These antibodies are strongly immunosuppressive and do not cause a significant release of cytokines. Furthermore, polynucleotides encoding said antibodies are described as well as vectors comprising said polynucleotides, host cells transformed therewith and their use in the production of said antibodies. Pharmaceutical compositions containing any of the above mentioned polynucleotides, antibodies or vectors are useful for immunotherapy, preferably against acute transplant rejections.