Gall bladder imaging agent and its preparation method
US9226982B2 · kind B2 · utility
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10Claims
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Key dates
| Filing date | Dec 30, 2013 |
| Grant date | Jan 5, 2016 |
| Priority date | — |
| Expiry date | Mar 29, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K51/0478
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A novel gall bladder image agent which includes a radio-labelled MAG3-tri-galactosamine, and its preparation method, which includes reacting mercaptoacetyltriglycine (MAG3)-tri-galactosamine, SnF2 and Tc-99m in the presence of a phosphate buffer solution (at pH of from 10.0˜12.0) to obtain Tc-99m-MAG3-tri-galactosamine, when the MAG3-tri-galactosamine is MAG3-DCM-Lys(Gah-GalNAc)3 (where DCM represents a dicarboxymethyl group, and Gah represents a glycine-aminohexyl group), it obtains a labelling yield of at least 90%, and its specific radioactivity is at least 7.0×109 Bq/mg.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.