Method for preparing 1-(4-chlorophenyl)-2-cyclopropyl-1-propanone and intermediate thereof
US9227900B2 · kind B2 · utility
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Key dates
| Filing date | Nov 18, 2013 |
| Grant date | Jan 5, 2016 |
| Priority date | — |
| Expiry date | Nov 18, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C41/30
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method is for preparing 1-(4-chlorophenyl)-2-cyclopropyl-1-propanone and an intermediate thereof, where in the method for preparing a compound of formula (I), α-alkoxy p-chlorobenzyl phosphonate (II) and cyclopropyl methyl ketone are used as raw materials, and subjected to a Homer-Wadsworth-Emmons reaction in an organic solvent in the presence of a base, so as to prepare a derivative of alkoxy propylene with the structure of formula (III); and the resulting derivative of alkoxy propylene (III) is hydrolyzed under acidic conditions to obtain 1-(4-chlorophenyl)-2-cyclopropyl-1-propanone (I).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.