Dopamine D3 receptor ligands and preparation and medical uses of the same

US9227944B2 · kind B2 · utility

Assignee

• INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY SCIENCE P.L.A. CHINA · CN

Inventors

• Jin Li · 安丰镇, CN
• Rifang Yang · Beijing, CN
• Rui Song · Beijing, CN
• Hui Zhu · Shanghai, CN
• Ning Wu · Boston, US
• Liuhong Yun · Beijing, CN
• Ruibin Su · Beijing, CN
• Rusheng Zhao · Beijing, CN

Key dates

• Filing date: Jun 3, 2014
• Grant date: Jan 5, 2016
• Expiry date: Jun 3, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a novel piperazine derivative represented by Formula I having an activity for regulating dopamine D3 receptor, stereoisomers thereof, pharmaceutically acceptable salts or solvates, and a pharmaceutical composition comprising the compound, a process for preparing the same, and use thereof in the prevention or treatment of a disease associated with central nervous system dysfunction, such as Parkinson's disease, schizophrenia, drug addiction and relapse, as well as kidney protection and immunoregulation, or as a tool for researching D3R function or diseases associated with D3R dysfunction.