Intracellular viral vector delivery method employing iron ion/viral vector composite
US9228202B2 · kind B2 · utility
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5Claims
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Key dates
| Filing date | Sep 28, 2010 |
| Grant date | Jan 5, 2016 |
| Priority date | — |
| Expiry date | Dec 12, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2810/10
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to an intracellular viral vector delivery method employing an iron ion/viral vector composite. The iron ion/viral vector composite according to the present invention is not dependent on the expression of CAR and so improves the efficiency of delivery of viral vectors and gene expression in cells of diverse types, and has an outstanding virus-neutralizing antibody escape performance, exhibits little cytotoxicity and is outstandingly stable even when subjected to iron ion processing at low concentration, and hence can be used to advantage in recombinant viral vaccine compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.