Process for the enantioselective enzymatic reduction of hydroxy keto compounds

US9228214B2 · kind B2 · utility

Assignee

• CAMBREX IEP GMBH · DE

Inventors

• Antje Gupta · Wiesbaden, DE
• Maria DUPONT · Gerstungen, DE
• Anke Tschentscher · Eltville am Rhein, DE

Key dates

• Filing date: Feb 4, 2015
• Grant date: Jan 5, 2016
• Expiry date: Feb 4, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N9/0008
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

In a process for the enantioselective enzymatic reduction of a hydroxy ketone of general formula Iwherein R1═C1-C6 alkyl and R2═—Cl, —CN, —OH, —H or C1-C6 alkyl, into a chiral diol of general formula IIwherein R1 and R2 have the same meaning as in formula I, the hydroxy ketone is reduced with an oxidoreductase in the presence of NADH or NADPH as a cofactor, wherein