Layer-by-layer quantification of the remodeling of the human fovea in neurodegenerative disease
US9230045B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Feb 15, 2012 |
| Grant date | Jan 5, 2016 |
| Priority date | — |
| Expiry date | Jul 23, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16H50/50
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A system and method for layer-by-layer quantification of the remodeling of the human fovea comprises finding a fixed reference point in inner retina, measuring the thickness of the inner retina at the fixed reference point, for a range of finely sampled distances starting from the fixed reference point, measuring the thickness, comparing the measured thickness with a normative base and obtaining a plurality of curves, evaluating area for each curve and defining a distance from the fixed reference having highest sensitivity with respect to the fixed reference point compared to the normative base, displaying a 3D re-creation of foveal architecture-based color-coded picture in accordance with the measured thickness at each finely sampled distance, entering the measured thickness into a model having parameters, obtaining numerical solutions for each parameter, and defining percent change of the parameters for the patient versus the parameters for the control.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.