Inhibition of WDR5 interaction with its binding partners

US9233086B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Shaomeng Wang · Saline, US
• Hacer Karatas · Ann Arbor, US
• Yali Dou · Ann Arbor, US
• Elizabeth Townsend · Ann Arbor, US
• Denzil Bernard · Ann Arbor, US

Key dates

• Filing date: Jun 14, 2011
• Grant date: Jan 12, 2016
• Expiry date: Feb 12, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Peptidomimetics that inhibit the interaction between MLL1 and WDR5 are disclosed. Methods of inhibiting MLL1 activity and methods of treating cancers also are disclosed.