Minicircle DNA vector preparations and methods of making and using the same
US9233174B2 · kind B2 · utility
37Cited by
4References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 2, 2015 |
| Grant date | Jan 12, 2016 |
| Priority date | — |
| Expiry date | Feb 2, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides minicircle nucleic acid vector formulations for use in administering to a subject, wherein the minicircle nucleic acid vectors include a polynucleotide of interest, a product hybrid sequence of a unidirectional site-specific recombinase, and are devoid of plasmid backbone bacterial DNA sequences. Also provided are methods of producing the subject formulations as well as methods for administering the minicircle nucleic acid vector formulations to a subject. The subject methods and compositions find use in a variety of different applications, including both research and therapeutic applications.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.