4,4-disubstituted-1,4-dihydropyrimidines and the use thereof as medicaments for the treatment of hepatitis B

US9233933B2 · kind B2 · utility

Assignee

• Janssen Sciences Ireland UC · IE

Inventors

• Koen Vandyck · Beringen, BE
• Geerwin Yvonne Paul Haché · Brasschaat, BE
• Geert Rombouts · Borsbeek, BE
• Wim Gaston Verschueren · Berchem, BE
• Pierre Jean-Marie Bernard Raboisson · Sligo, IE

Key dates

• Filing date: Jan 4, 2013
• Grant date: Jan 12, 2016
• Expiry date: Jan 4, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/107
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Inhibitors of HBV replication of formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein R1-R5, B and Z have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.