Process for the preparation of azilsartan medoxomil

US9233955B2 · kind B2 · utility

Assignee

• Jubilant Life Sciences Limited · IN

Inventors

• Deepak Bansal · Sidhauli, IN
• Himanchal Mishra · Sidhauli, IN
• Shailendr Kumar Dubey · Sidhauli, IN
• Alka Srivastava Choudhary · Sidhauli, IN
• Dharam Vir · Sidhauli, IN
• Ashutosh Agarwal · Ghaziabad, IN

Key dates

• Filing date: Jan 24, 2012
• Grant date: Jan 12, 2016
• Expiry date: Mar 25, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to an improved process for the preparation of azilsartan or its esters or salts thereof. Specifically, the invention provides a method for the preparation of highly pure methyl 1-[[2′-(4,5-dihydro-5-oxo-4H-1,2,4-oxa-diazol-3-yl)biphenyl-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate an intermediate compound of formula (4) for azilsartan medoxomil with reduced content of desethyl impurity. The invention also involves the use of highly pure methyl 1-[[2′-(4,5-dihydro-5-oxo-4H-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate in the preparation of azilsartan or its esters or salts thereof, preferably medoxomil with reduced content of desethyl impurity.