Substituted hetero-bicyclic compounds, compositions and medicinal applications thereof

US9233983B2 · kind B2 · utility

Assignee

• Advinus Therapeutics Limited

Inventors

• Mahesh Thakkar · Pune, IN
• Summon Koul · Pimpri-Chinchwad, IN
• Debnath Bhuniya · Pune, IN
• Kasim Mookhtiar · Jamkhed, IN
• Santosh Kurhade · Barwala, IN
• Yogesh Munot · Providence, US
• Tanaji Mengawade · Pune, IN
• Bheemashankar A. Kulkarni · Noida, IN

Key dates

• Filing date: Oct 8, 2014
• Grant date: Jan 12, 2016
• Expiry date: Oct 8, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides hetero-bicyclic compounds of formula (I), their tautomers, polymorphs, stereoisomers, prodrugs, solvates, hydrates, N-oxides, co-crystals, pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by Bruton's tyrosine kinase (Btk) activity, The disclosure also relates to the process of preparation of compounds of Formula (I).These compounds are useful in the treatment, prevention, prophylaxis, management, or adjunct treatment of all medical conditions related to inhibition of Bruton's tyrosine kinase (Btk), such as inflammatory and/or autoimmune disorder, cell proliferation, rheumatoid arthritis, psoriasis, psoriatic arthritis, transplant rejection, graft-versus-host disease, multiple sclerosis, inflammatory bowel disease, allergic diseases, asthma, type 1 diabetes, myasthenia gravis, hematopoetic disfunction, B-cell malignancies, systemic lupus, erythematosus or other disorders.