RGD mimetic γ-AApeptides and methods of use

US9234007B2 · kind B2 · utility

Assignees

• University of South Florida · US
• Wisconsin Alumni Research Foundation · US

Inventors

• Jianfeng Cai · Tampa, US
• Youhong Niu · Tampa, US
• Weibo Cai · Madison, US
• Hao Hong · Tianjin, CN

Key dates

• Filing date: Jun 18, 2013
• Grant date: Jan 12, 2016
• Expiry date: Jul 22, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K51/082
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Embodiments of the present disclosure provide for RGD mimetic γ-AApeptide compounds, γ-AApeptide compounds capable of binding an RGD binding site on integrin αvβ3, linear γ-AApeptide compounds, cyclic γ-AApeptide compounds and multimeric RGD mimetic γ-AApeptide compounds, methods of making each, and methods of using each, and the like. In embodiments, the RGD mimetic γ-AApeptide compounds can be used in imaging, diagnostics, and treatment of angiogenesis related conditions.