Crystal form I of (S)-4-hydroxy-2-oxo-1-pyrrolidine acetamide, preparing method and use thereof

US9238622B2 · kind B2 · utility

Assignee

• Chongqing Ruzer Pharmaceutical Co., Ltd · CN

Inventors

• Chao You · Chongqing, CN
• Hua Feng · Shanghai, CN
• Qi Pang · Chongqing, CN
• Lei Ye · Lund, SE
• Yuying Chen · Chongqing, CN
• Zuyuan Rong · Chongqing, CN
• Lei Jin · Unionville, US
• Nan XU · Shenyang, CN
• Fei Li · Nanhu, CN
• Bo Li · San Jose, US

Key dates

• Filing date: Sep 8, 2010
• Grant date: Jan 19, 2016
• Expiry date: Sep 8, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/28
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A crystal form I of (S)-4-hydroxy-2-oxo-1-pyrrolidine acetamide, or named (S)-oxiracetam, is provided, which is characterized by a powder x-ray diffraction pattern that exhibits data of d-values versus the relative intensities as: 7.075(M), 5.355(S), 5.092(S), 4.590(M), 4.325(M), 4.259(S), 4.041(VS), 3.808(M), 3.542(M), 3.445(M), 3.393(M), 2.972(M), 2.914(S). A method for preparing a crystal form I of (S)-oxiracetam is also provided, which includes preparing the crude product and crystallizing A use of the crystal form I of (S)-oxiracetam in the manufacture of a medicament for preventing and treating memory dysfunction is also provided. Accordingly, the crystal form I of (S)-oxiracetam prepared by the method has high purity of more than 99.3% based on the percentages of the mass, with better efficacy than (S)-oxiracetam for preventing or treating memory dysfunction. Concerning the way of charging materials, adding inorganic base only a few times is simpler and more beneficial to industrial manufacturing and application.