Polymeric prodrug with self-immolative linker

US9238686B2 · kind B2 · utility

Assignee

• Ascendis Pharma Inc. · DE

Inventors

• Ulrich Hersel · Heidelberg, DE
• Harald Rau · Würzburg, DE
• Robert Schnepf · Dossenheim, DE
• Dirk Vetter · Heidelberg, DE
• Thomas Wegge · Heidelberg, DE

Key dates

• Filing date: Feb 5, 2013
• Grant date: Jan 19, 2016
• Expiry date: Jan 3, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/62
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A cascade carrier linked prodrug is described comprising a biologically active moiety and a masking group having at least one nucleophile and being distinct from the carrier.