Compositions and methods for inhibiting human host factors required for influenza virus replication
US9238815B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Dec 10, 2010 |
| Grant date | Jan 19, 2016 |
| Priority date | — |
| Expiry date | Jan 15, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/365
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This application relates to the modulation of host cell factors required for influenza virus replication. The application relates to compounds, including nucleic acid compounds (such as, e.g., small interfering RNAs (siRNAs)) and small molecules, that target human host cell factors involved in influenza virus replication, and the use of such compounds for modulating influenza virus replication and as antiviral agents. The application also relates to methods of treating an influenza virus infection and methods of treating or preventing a symptom or disease associated with influenza virus infection, comprising administering to a subject a composition comprising a compound, such as a nucleic acid compound (e.g., an siRNA) or small molecule, that targets a human host cell factor involved in influenza virus replication.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.