Amyloid protein oligomer-binding aptamer

US9238816B2 · kind B2 · utility

Assignee

• NATIONAL UNIVERSITY ORPORATION TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY · JP

Inventors

• Kazunori Ikebukuro · Fuchu, JP
• Kaori Tsukakoshi · Saitama, JP
• Koji Sode · Tokyo, JP

Key dates

• Filing date: Feb 20, 2012
• Grant date: Jan 19, 2016
• Expiry date: Sep 6, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/50
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

An aptamer having a G-quartet structure and being at least one selected from the group consisting of the following polynucleotides, the aptamer having a binding ability to an amyloid protein oligomer: (1) a polynucleotide comprising a base sequence represented by any one of SEQ ID NO:1 to SEQ ID NO:18; (2) a polynucleotide comprising a base sequence that includes at least four sets of at least two consecutive guanosine nucleotides and in which one or several bases has been deleted, substituted, or added in a base sequence represented by any one of SEQ ID NO:18; and (3) a polynucleotide that is a multimer including the polynucleotide of (1) or (2) as a structural unit.