Patent · US Active

Aripiprazole medicament formulation and preparation method therefor

US9241876B2 · kind B2 · utility

4Cited by

1References

31Claims

0Family size

Assignee

SHANGHAI ZHONGXI PHARMACEUTICAL CORPORATION · CN

Inventors

Siji Zheng · Shanghai, CN
Xiaoyi Liu · Cupertino, US
Linyong Fu · Shanghai, CN
Bo Tan · Tangxia, CN
Min Zhou · Suzhou, CN

Key dates

Filing date	Jun 26, 2012
Grant date	Jan 26, 2016
Priority date	—
Expiry date	Jun 26, 2032

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P25/18
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The preparation method includes the following steps: dissolving aripiprazole in an acidic solution having an acidifier so as to obtain a medicament having acidic solution; then, performing a wet granulation on or preparing a suspension with the obtained medicament having acidic solution, an alkalizer, and an excipient so as to obtain the aripiprazole medicament formulation; the excipient comprising an antioxidant. The aripiprazole medicament formulation obtained through the preparation method has a significantly reduced amount of related substances, great solubility, great stability, high bioavailability, reduced individual differences, and enhanced wettability and content uniformity of insoluble medicaments.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.