Patent · US Active

Photochemical internalisation of kinase inhibitors

US9241996B2 · kind B2 · utility

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0References

27Claims

0Family size

Assignee

PCI BIOTECH AS · NO

Inventors

Anders Høgset · Oslo, NO
Anette Weyergang · Oslo, NO
P{dot over (a)}l Kristian Selbo · Oslo, NO
Kristian Berg · Heggedal, NO

Key dates

Filing date	Jun 26, 2009
Grant date	Jan 26, 2016
Priority date	—
Expiry date	Jan 17, 2032

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P43/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to a method for enhancing the activity of kinase inhibitors in target cells, and more specifically for enhancing the activity of tyrosine kinase inhibitors (TKIs), said method comprising contacting a cell with a kinase inhibitor and a photosensitizing agent and irradiating said cell with light of a wavelength effective to activate the photosensitizing agent, and to the use of this method for enhancing the effects of kinase inhibitors or kinase inhibitor-based drugs in particular to achieve cell death, for example, in cancer treatment and other diseases or conditions in which kinase inhibitors, such as TKIs, have a beneficial effect.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.