Process for the preparation of oxindoles and ortho-substituted anilines and their use as intermediates for syntheses
US9242934B2 · kind B2 · utility
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12Claims
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Key dates
| Filing date | Jun 12, 2013 |
| Grant date | Jan 26, 2016 |
| Priority date | — |
| Expiry date | Jun 12, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C323/58
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to processes for the preparation of oxindoles and ortho-substituted anilines and their use as intermediates for syntheses. The invention further relates to a process for the preparation of compounds of formula (4):where a mixture of an aniline (compound of formula Q) is reacted with a thioether (compound of formula W):in the presence of a chlorinating agent and an organic solvent at a reaction temperature in the range above −65° C.In a subsequent process, this compound is further reacted in the presence of an acid catalyst to give the indole of formula (7) or the oxindole of formula (8):
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.