Glycine reuptake inhibitor and use thereof

US9242938B2 · kind B2 · utility

Assignees

• Beijing Medisan Technology Co., Ltd · CN
• HARBIN MEDISAN PHARMACEUTICAL CO., LTD. · CN

Inventors

• Jinai Liu · 南口镇, CN
• Mingxin Wang · 南口镇, CN
• Fan Yang · Brookline, US
• Ailing Wang · 南口镇, CN
• Yan Zhu · Beijing, CN
• Jin Cui · 南口镇, CN
• Lei Ji · Jinan, CN

Key dates

• Filing date: Nov 21, 2012
• Grant date: Jan 26, 2016
• Expiry date: Nov 21, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/81
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are a glycine reuptake inhibitor and the use thereof. The glycine reuptake inhibitor is a compound of formula I, or isomers, pharmaceutically acceptable salts or solvates thereof, wherein R1 is one or more groups selected from hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, nitro, cyano, amino, hydroxyl, C1-6 haloalkyl, and C1-6 haloalkoxy; R2 is selected from hydrogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, and C1-6 haloalkoxy; and each of R3 and R4 is independently selected from hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, nitro, cyano, amino, hydroxyl, C1-6 haloalkyl, and C1-6 haloalkoxy.