Lactol and acetal intermediates for making prostaglandins

US9242954B2 · kind B2 · utility

Assignee

• The University of Bristol · GB

Inventors

• Varinder Kumar Aggarwal · Bristol, GB
• Mark Graeme Coulthard · Bristol, GB
• William Erb · Bristol, GB

Key dates

• Filing date: Jun 11, 2013
• Grant date: Jan 26, 2016
• Expiry date: Jun 11, 2033

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A compound of formula (I): (I) wherein Y is, Z is OR10, NR11R11 SR11, S(O)R11 SO2R11, R10 is H, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, CO—R11, or a protecting group, and R11 is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, or alkoxyl; a process for making a compound of formula (I); and a process for making a prostaglandin or a prostaglandin analog using a compound of formula (I).