Structural mimetics of proline-rich peptides and use thereof

US9242985B2 · kind B2 · utility

Assignees

• Forschungsverbund Berlin e.V. · DE
• UNIVERSITÄT ZU KÖLN · DE

Inventors

• Ronald Kühne · Berlin, DE
• Hartmut Oschkinat · Berlin, DE
• Robert Opitz · Rochester, US
• Matthias Müller · Konstanz, DE
• Hans-Günther Schmalz · Bogen, DE
• Cedric Reuter
• Peter Huy · Korschenbroich, DE

Key dates

• Filing date: Aug 24, 2012
• Grant date: Jan 26, 2016
• Expiry date: Aug 24, 2032

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to compounds that can be used, in particular, as structural mimetics of proline-rich peptides and are correspondingly able to bond with proline-rich-motif binding domains (PRM domains) of proteins. The invention further relates to the use of these compounds as pharmaceutically active agents, as well as the use of the pharmaceutically active agents for the treatment of bacterial, neurodegenerative and tumor diseases.