Phosphate ester compound of hydroxy acid substituted phenol ester, preparation method and medical use thereof
US9243009B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Oct 13, 2010 |
| Grant date | Jan 26, 2016 |
| Priority date | — |
| Expiry date | Oct 19, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/091
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Phosphate ester compound of hydroxy acid substituted phenyl ester, preparation method and medical use thereof are provided. The title compound is shown in formula (I), in which Y═C1-4 straight carbon chain, M1 and/or M2=H, alkali metal ion, protonated amine or protonated amino acid. The compound has good water solubility and high stability in its aqueous solution, and it can release 2,6-diisopropylphenol rapidly under the action of enzymes in vivo, which has the effects of sedation, hypnosis and/or anesthesia. By protecting hydroxyl of 2,6-diisopropylphenol in compound of formula (I), the first-pass metabolic activity of 2,6-diisopropylphenol is reduced, so that the synthetic compound can be used for sedation, hypnosis and/or anesthesia.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.