Patent · US Active

Anticoagulant polypeptide and applications thereof

US9243044B2 · kind B2 · utility

0Cited by

0References

12Claims

0Family size

Assignee

GUANGDONG MEDICAL COLLEGE · CN

Inventors

Lifei Peng · Zhanjiang, CN
Weiqiong Gan · Zhanjiang, CN
Zheng Shao · Zhanjiang, CN
Qingfeng He · Durham, US
Li Deng · Zhanjiang, CN
Jingjing Hu · Shanghai, CN
Shuli Liao · Zhanjiang, CN
Jida Peng · Zhanjiang, CN

Key dates

Filing date	Apr 5, 2012
Grant date	Jan 26, 2016
Priority date	—
Expiry date	Apr 5, 2032

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed is an anticoagulant polypeptide and applications thereof. The anticoagulant polypeptide comprises a polypeptide formed by an amino acid sequence as represented in Seq. ID No. 1; or comprises a derived polypeptide that selectively inhibits coagulation factor XIa and is formed by an amino acid sequence, as represented in Seq. ID No. 1, that has undergone one or multiple amino acid residue substitutions, deletions, or insertions. The anticoagulant polypeptide is a selective inhibitor for coagulation factor XIa, has anticoagulant activity and small side-effect, and can be used in preparing medicines for the prevention and treatment of thrombotic diseases.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.