Use of stabilized granules containing glyceryl trinitrate for arteriogenesis
US9248099B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | May 29, 2013 |
| Grant date | Feb 2, 2016 |
| Priority date | — |
| Expiry date | Aug 15, 2033 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/616
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention inter alia relates to a method of treating or preventing an arterial insufficiency, wherein an NO donor is administered in an intermitting manner to a subject in an amount effective for the induction of arteriogenesis, and wherein the NO donor is a solid pharmaceutical preparation with the active substance glyceryl trinitrate for oromucosal or oral administration characterized in that it contains between 0.05 and 2 weight % glyceryl trinitrate (GTN), at least one diluent, one carrier material, and at least one substance that reduces the volatility of GTN, whereby this substance is a non-volatile ester stabilizer whose melting point is not higher than 60° C.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.