pH sensitive carrier and preparation method thereof, and pH sensitive drug and pH sensitive drug composition each containing the carrier, and method for treating or preventing diseases using the same
US9248192B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | May 31, 2013 |
| Grant date | Feb 2, 2016 |
| Priority date | — |
| Expiry date | May 31, 2033 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/28
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A pH sensitive carrier which includes at least one pH sensitive compound selected from the group consisting of deoxycholic acid, cholic acid, ursodeoxycholic acid, chenodeoxycholic acid, hyodeoxycholic acid, C27 bile acid, glycodeoxycholic acid, glycyrrhizic acid, glycyrrhetinic acid and salts thereof, and at least one amphipathic substance selected from the group consisting of a phosphatidylcholine having 10 to 12 carbon atoms, a polyoxyethylene sorbitan monofatty acid ester having 12 to 18 carbon atoms, a sorbitan fatty acid ester having 16 to 18 carbon atoms, glycerol monooleate, glycerol dilaurate, glycerol distearate, glycerol dioleate, polyoxyethylene castor oil and α-tocopherol, and which is capable of developing a membrane disruptive function promoting effect.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.