Aniline derivatives, their preparation and their therapeutic application

US9249085B2 · kind B2 · utility

Assignee

• FOVEA PHARMACEUTICALS · FR

Inventors

• John Thomas Feutrill · Waltham, US
• Caroline Leriche · Paris, FR
• David Middlemiss · Chelmsford, GB

Key dates

• Filing date: Sep 7, 2012
• Grant date: Feb 2, 2016
• Expiry date: Sep 7, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/088
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to aniline derivatives of formula (I), to their preparation and to their therapeutic application, for example in treating glaucoma: Formula (I), R1a represents H, an halogen, a (C1-C6)alkyl or a CN; R1b represents H, an halogen or a (C1-C6)alkyl; R1c represents H or a (C1-C6)alkyl; R2 represents H, an halogen, an OH, an O—(C1-C6)alkyl or (C1-C6)alkyl; R3 represents H, an halogen, a (C1-C6)alkyl, an OH, an O—(C1-C6)alkyl, a CONH2 or CN; R4 represents H, an halogen or a (C1-C6)alkyl; R5 represents H or F: R7 represents H or F; R8 represents H or F; R9 represents H or (C1-C6)alkyl, or one of its enantiomers.