Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds

US9249144B2 · kind B2 · utility

Assignee

• OPKO Health, Inc. · US

Inventors

• George G. Wu · Berkeley Heights, US
• Gerald Werne · Ketsch, DE
• Xiaoyong Fu · Edison, US
• Robert K. Orr · Brooks Road, US
• Frank Xing Chen · Plainsboro, US
• Jian Cui · Edison, US
• Victoria M. Sprague · Bound Brook, US
• Fucheng Zhang · Laishui, CN
• Ji Xie · Edison, US
• Liansheng Zeng · Union, US
• Louis Peter Castellanos · Union City, US
• Yuyin Chen · Garwood, US
• Marc Poirier · Edison, US
• Ingrid Mergelsberg · Mahwah, US

Key dates

• Filing date: Oct 1, 2013
• Grant date: Feb 2, 2016
• Expiry date: Oct 1, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes.