Patent · US Active

Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production

US9249177B2 · kind B2 · utility

1Cited by

4References

11Claims

0Family size

Assignee

K.U. Leuven Research & Development · BE

Inventors

Piet Herdewijn · Wezemaal, BE
Christophe Pannecouque · Heverlee, BE
Tongfei Wu · Leuven, BE
Erik De Clercq · Lovenjoel, BE

Key dates

Filing date	Jun 27, 2014
Grant date	Feb 2, 2016
Priority date	—
Expiry date	Jun 27, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07H19/16
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The invention is directed to processes of preparing phosphonate nucleosides comprising a phosphonalkoxy-substituted five-membered, saturated or unsaturated, oxygen-containing ring coupled to a heterocyclic nucleobase such as a pyrimidine or purine base. These compounds can be described by the general formula (XIX)

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.