Purification of antibodies using hydrophobic interaction chromatography
US9249182B2 · kind B2 · utility
31Cited by
149References
45Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 14, 2013 |
| Grant date | Feb 2, 2016 |
| Priority date | — |
| Expiry date | Mar 14, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K16/241
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
Disclosed herein are compositions and methods for purifying antibody products from a sample matrix. In particular, the present invention relates to compositions and methods for purifying antibody products employing hydrophobic interaction chromatography media. In certain embodiments, the invention provides a method for reducing process-related impurities (e.g., host cell proteins), as well as product-related substances, including molecular weight variants (e.g., aggregates and fragments of the antibody product).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.