Method of suppressing gene transcription through histone lysine methylation
US9249190B2 · kind B2 · utility
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42Claims
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Key dates
| Filing date | Oct 1, 2010 |
| Grant date | Feb 2, 2016 |
| Priority date | — |
| Expiry date | Jul 18, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y201/01043
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to methods of suppressing the transcriptional expression of one or more genes by methylating the chromatin histone proteins of the one or more genes. Specifically, a viral SET domain histone lysine methyltransferase (vSET or vSET-like protein) methylates lysine 27 of a gene's histone protein 3 (H3-K27) thereby suppressing the transcription of the gene.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.