Lentiviral vectors pseudotyped with mutant BaEV glycoproteins
US9249426B2 · kind B2 · utility
4Cited by
2References
13Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Sep 28, 2012 |
| Grant date | Feb 2, 2016 |
| Priority date | — |
| Expiry date | Sep 28, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2810/6054
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention concerns a pseudotyped viral vector particle for transferring biological material into cells, wherein said vector particle comprises at least:—a chimeric envelope glycoprotein which comprises or consists in a fusion of the transmembrane and extracellular domain of a baboon endogenous retrovirus (BaEV) envelope glycoprotein and the cytoplasmic tail domain of a murine leukemia virus (MLV) envelope glycoprotein; or—a modified BaEV envelope glycoprotein wherein the cytoplasmic tail domain is devoid of the fusion inhibitory R peptide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.