Recombinant microorganisms having phosphoketolase activity and diminished phosphofructokinase activity and/or glucose-6 phosphate dehydrogenase activity
US9249430B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Jul 12, 2012 |
| Grant date | Feb 2, 2016 |
| Priority date | — |
| Expiry date | Jul 12, 2032 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/52
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Described are recombinant microorganisms characterized by having phosphoketolase activity, having a diminished or inactivated Embden-Meyerhof-Parnas pathway (EMPP) by inactivation of the gene(s) encoding phosphofructokinase or by reducing phosphofructokinase activity as compared to a non-modified microorganism and having a diminished or inactivated oxidative branch of the pentose phosphate pathway (PPP) by inactivation of the gene(s) encoding glucose-6-phosphate dehydrogenase or by reducing glucose-6-phosphate dehydrogenase activity as compared to a non-modified microorganism. These microorganisms can be used for the production of useful metabolites such as acetone, isobutene or propene.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.