Magnetic separation of lipoproteins using dextran sulfate
US9250211B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 29, 2011 |
| Grant date | Feb 2, 2016 |
| Priority date | — |
| Expiry date | Dec 29, 2031 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N27/622
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention provides apparatus and methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged-particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged-particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.