Autophagy and phospholipidosis pathway assays
US9250249B2 · kind B2 · utility
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17Claims
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Key dates
| Filing date | Sep 14, 2009 |
| Grant date | Feb 2, 2016 |
| Priority date | — |
| Expiry date | Aug 3, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/52
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Provided are assays useful for detecting and monitoring autophagy and phospholipidosis, including the progression of lysosomal storage diseases. Drugs and treatments for lysosomal storage diseases can be monitored for effectiveness in lysosomal storage disease conditions. Drug candidates and suspected toxic agents can also be screened for toxicity to cells, tissues and organs. Also provided are methods for distinguishing between phospholipidosis activators and autophagy pathway perturbation agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.