System and method for optical imaging with vertical cavity surface emitting lasers
US9253419B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 24, 2012 |
| Grant date | Feb 2, 2016 |
| Priority date | — |
| Expiry date | Mar 17, 2034 |
Classification
- Technology area (CPC H)Electricity
- CPC primaryH04N23/56
- WIPO fieldAudio-visual technology
- WIPO sectorElectrical engineering
Abstract
The present invention uses vertical-cavity surface-emitting lasers (VCSELs) as illumination source for simultaneous imaging of blood flow and tissue oxygenation dynamics in vivo, or a means to monitor neural activity in brain slices ex vivo. The speckle pattern on the brain tissue due to a VCSEL's coherence properties is the main challenge to producing low-noise high-brightness illumination, required for evaluating tissue oxygenation. Moreover, using oxide-confined VCSELs we show a fast switching from a single-mode operation scheme to a special multi-modal, multi-wavelength rapid sweep scheme. The multi-modal, multi-wavelength rapid sweep scheme reduces noise values to within a factor of 40% compared to non-coherent LED illumination, enabling high-brightness VCSELs to act as efficient miniature light sources for various brain imaging modalities and other imaging applications. These VCSELs are promising for long-term portable continuous monitoring of brain dynamics in freely moving animals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.