Control of hypoxia-inducible gene expression with oligooxopiperazine nonpeptidic helix mimetics
US9255086B2 · kind B2 · utility
10Cited by
1References
35Claims
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Key dates
| Filing date | Feb 19, 2013 |
| Grant date | Feb 9, 2016 |
| Priority date | — |
| Expiry date | Feb 19, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/63
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to oligooxopiperazines that mimic helix αB of the C-terminal transactivation domain of HIF-1α. Also disclosed are pharmaceutical compositions containing these oligooxopiperazines and methods of using these oligooxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF-1α with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.