Methods for the Preparation of HIV attachment inhibitor piperazine prodrug compound

US9255113B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Martin D. Eastgate · Titusville, US
• Michael S. Bultman · Allendale, US
• Ke Chen · Sichuan, CN
• Dayne Dustan Fanfair · Plainsboro, US
• Richard J. Fox · Kirkwood, US
• Thomas E. La Cruz · New Brunswick, US
• Boguslaw M. Mudryk · Plainsboro, US
• Christina Ann Risatti · Princeton, US
• James H. Simpson · Fryeburg, US
• Maxime C. Soumeillant · Hamilton Square, US
• Jonathan Clive Tripp · San Mateo, US
• Yi Xiao · Fanwood, US

Key dates

• Filing date: Oct 17, 2014
• Grant date: Feb 9, 2016
• Expiry date: Nov 15, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6561
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A method for making the compoundis set forth utilizing the starting materialwherein R7═—H, alkyl, aryl, —SO2R, —C(O)OR, and —C(O)NR2; where R═—H, C1-C6 alkyl, -aryl, and —CH2Aryl.