Identification of surface-associated antigens for tumor diagnosis and therapy

US9255131B2 · kind B2 · utility

Assignee

• Ganymed Pharmaceuticals GmbH · DE

Inventors

• Ozlem Tureci · Homburg, DE
• Ugur Sahin · Mainz, DE
• Sandra Schneider · Blankenloch, DE
• Gerd Helftenbein · Mücke, DE
• Volker Schlüter · Schwanau, DE
• Dirk Usener · Wiesbaden, DE
• Philippe Thiel · Planegg, DE
• Michael Koslowski · Mainz, DE

Key dates

• Filing date: Aug 6, 2010
• Grant date: Feb 9, 2016
• Expiry date: Nov 10, 2032

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/53
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An isolated truncated desmoglein 4 (DSG4) polypeptide splice variant of the invention is characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75. Also disclosed is a method of diagnosing a cancer, or monitoring the course thereof, in a patient. The method comprises detecting in a tissue sample of a patient the expression of a tumor-associated antigen comprising the extracellular domain of a DSG4 polypeptide encoded by a DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75, or a truncated DSG4 polypeptide splice variant characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene.