GNTIII expression in plants

US9255277B2 · kind B2 · utility

Assignee

• Stichting Dienst Landbouwkundig Onderzoek-PPO/PRI · NL

Inventors

• Hendrikus Antonius Cornelis Bakker · Hannover, DE
• Dionisius Elisabeth Antonius Florack · Wageningen, NL
• Hendrik Jan Bosch · Utrecht, NL

Key dates

• Filing date: Jun 19, 2013
• Grant date: Feb 9, 2016
• Expiry date: Aug 5, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P21/02
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention relates to the field of glycoprotein processing in transgenic plants used as cost efficient and contamination safe factories for the production of recombinant biopharmaceutical proteins or pharmaceutical compositions comprising these glycoproteins. The invention provides a plant comprising a functional mammalian enzyme providing mammalian GnTIII that is normally not present in plants, said plant additionally comprising at least a second mammalian protein or functional fragment thereof that is normally not present in plants.