Systems and methods for biodosimetry with biochip using gene expression signatures

US9255348B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Frederic Zenhausern · Fountain Hills, US
• Christine Orozco · Mystic, US
• Mark Richards · Brighton, US
• Carl Yamashiro · Chandler, US
• Sally A. Amundson · Rockville, US
• Ralf Lenigk · Niskayuna, US
• Michael L. Bittner · Rockville, US
• Yoganand Balagurunathan · College Station, US

Key dates

• Filing date: Aug 24, 2007
• Grant date: Feb 9, 2016
• Expiry date: Jul 5, 2032

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01L2300/1827
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

Exposure to ionizing radiation can produce a well-defined dose dependent signature in terms of changes in gene expression. In approaches and devices described herein, such a signature can be used to generate and use a self-contained radiation biodosimeter device, based on, for example, a blood finger stick. Various aspects of the invention are directed to biodosimetry with a fully integrated biochip using gene expression signatures.