Urea compounds and use thereof for inhibiting apoptosis

US9260384B2 · kind B2 · utility

Assignee

• CHINESE PLA GENERAL HOSPITAL · CN

Inventors

• Kunlun He · Baofeng County, CN
• Song Li · Beijing, CN
• Wu Zhong · Beijing, CN
• Juan Liu · 安丰镇, CN
• Lili Wang · Beijing, CN
• Xin Li · Shanghai, CN
• Guoliang Hu · Nanchang, CN
• Long Long · Beijing, CN
• Junhai Xiao · Beijing, CN
• Zhibing Zheng · Beijing, CN
• Wei Li · Lexington, US
• Ruijun Li · Parramatta, AU
• Chunlei Liu · Shanghai, CN
• Jie Bai · Beijing, CN

Key dates

• Filing date: May 14, 2010
• Grant date: Feb 16, 2016
• Expiry date: Dec 6, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D215/40
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of Formula I, or an isomer, pharmaceutically acceptable salt or solvate thereof, is provided. Also, a composition containing a compound of Formula I, or an isomer, pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluents, is provided. Further, use of a compound of Formula I, or an isomer, pharmaceutically acceptable salt or solvate thereof for anti-apoptosis is provided, preventing or treating a disease or disorder associated with apoptosis; especially for protecting cardiomyocyte, preventing or treating a disease or disorder associated with cardiomyocyte apoptosis.