Hypoglycemic dihydropyridones

US9260391B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Yuli Xie · Shanghai, CN
• Shixian Deng · White Plains, US
• Donald W. Landry · New York, US
• Paul William Richard Harris · Richmond, US
• Antonella Maffei · New York, US

Key dates

• Filing date: Aug 7, 2009
• Grant date: Feb 16, 2016
• Expiry date: Nov 23, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides, inter alia, a compound of formula I: wherein the substituent designations are indicated in the Specification. The present invention also provides pharmaceutical compositions comprising a compound of formula I, and methods of treatment or prevention of diabetes or hyperglycemia in a patient, and of normalizing blood glucose levels in a subject, by administering an effective amount of a compound of formula I.