Patent · US Active

Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds

US9260428B2 · kind B2 · utility

1Cited by

24References

9Claims

0Family size

Assignee

OPKO Health, Inc. · US

Inventors

Ingrid Mergelsberg · Mahwah, US
Dominik Hermann Scherer · Horw, CH
Monika Erika Huttenloch · Kriens, CH
Hon-Chung Tsui · East Brunswick Township, US
Sunil Paliwal · Manalapan, US
Neng-Yang Shih · Lexington, US

Key dates

Filing date	Sep 27, 2013
Grant date	Feb 16, 2016
Priority date	—
Expiry date	Sep 27, 2033

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D498/10
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

This application discloses a process to synthesize 8-({1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy)-methyl]-8-pheny-1.7-diaza-spiro[4.5]decan-2-one comprising reacting a compound of the Formula 27a-sulfonate with zinc in the presence of acetic acid.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.