Antibodies that are capable of specifically binding tissue factor pathway inhibitor
US9260518B2 · kind B2 · utility
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2References
16Claims
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Assignee
Inventors
Key dates
| Filing date | Jun 30, 2011 |
| Grant date | Feb 16, 2016 |
| Priority date | — |
| Expiry date | Jun 30, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/76
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to antibodies that are capable of specifically binding tissue factor pathway inhibitor (TFPI), neutralising free TFPI and reducing the clotting time of blood. Furthermore, the invention relates to polynucleotides that encode such antibodies and to cells that comprise the polynucleotides or that express the antibodies of the invention. Such antibodies have utility in the treatment of subjects with a coagulopathy, alone as well as in combination with a second agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.