Antibody molecules to oncogenic isoforms of fibroblast growth factor receptor-2 and uses thereof
US9260525B2 · kind B2 · utility
Inventors
Key dates
| Filing date | Feb 12, 2013 |
| Grant date | Feb 16, 2016 |
| Priority date | — |
| Expiry date | Jul 14, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/92
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Antibody molecules that specifically bind to one or more isoforms expressed and/or associated with oncogenic phenotypes in a hyperproliferative cell (e.g., a cancerous or tumor cell) are disclosed. The isoform-binding antibody molecules can be used to treat, prevent and/or diagnose cancerous conditions and/or disorders. Methods of using the isoform-binding molecules to selectively detect oncogenic isoforms, to reduce the activity and/or induce the killing of a hyperproliferative cell expressing an oncogenic isoform in vitro, ex vivo or in vivo are also disclosed. Diagnostic and/or screening methods and kits for evaluating the function or expression of an oncogenic isoform are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.