Cyclopentapeptide derivatives and uses thereof

US9266924B2 · kind B2 · utility

Assignee

• TECHNISCHE UNIVERSITÄT MÜNCHEN · DE

Inventors

• Oliver Demmer · Birkenfeld, DE
• Horst Kessler · Schwalbach, DE
• Hans-Jürgen Wester · Ilmmünster, DE
• Margret Schottelius · Munich, DE
• Ingrid Dijkgraaf · Neubiberg, DE
• Andreas Konard Buck · Munich, DE

Key dates

• Filing date: Apr 20, 2011
• Grant date: Feb 23, 2016
• Expiry date: Oct 14, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K51/088
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention, among others, relates to a compound having a structure according to formula (I) or a pharmaceutically acceptable salt thereof, wherein Xaa1 to Xaa4 are independently of each other, an optionally N-alkylated natural or unnatural amino acid, R is H or methyl, L is a linker moiety, Ar is a spacer comprising an aromatic moiety, and D comprises, preferably is i) a combination of an organic complexation agent and a detectable label; or ii) a detectable label, an organic complexation agent or an active substance, said active substance particularly being selected from cytotoxic agents, lipids, sugars, sugar conjugates, sugar derivatives, proteins and combinations thereof, with the proviso that -L-Ar-D does not comprise a 18F-benzoyl residue.